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Long-term complications are the most devastating aspect of both forms of diabetes. The pathophysiology leading to these complications is incompletely understood, and the therapeutic options currently available are limited and only partially effective.
Diabetic complications are the end result of the metabolic syndrome and uncontrolled diabetes, mainly hyperglycemia, which results in over action of key intracellular enzymes. Diabetes is a major cause of blindness, dialysis, amputations, and cardiovascular morbidity and mortality worldwide.
Because of our limited ability to reverse the metabolic syndrome and control blood glucose levels, there is an urgent need for drugs that will prevent the abnormal activation of the intracellular enzymes that may lead to these complications. This section includes studies aimed at understanding the mechanisms that cause these complications, with the ultimate goal of identifying targets for novel drug development.
D Cure Supported Research on Diabetes Complications
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